The inhibition of tyrosine kinase receptor signalling in leiomyosarcoma cells using the small molecule kinase inhibitor PTK787/ZK222584 (Vatalanib®)

The inhibition of tyrosine kinase receptor signalling in leiomyosarcoma cells using the small molecule kinase inhibitor PTK787/ZK222584 (Vatalanib®)

Leiomyosarcomas remain challenging tumors to manage and novel therapy strategies besides radiation and conventional chemotherapy are needed. Targeting angiogenesis by inhibition of vascular endothelial growth factor (VEGF) receptor tyrosine kinases (RTKs) of the tumor vasculature with small molecule...

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Bibliographic Details
Main Authors: GAUMANN, ANDREAS K.A., DREXLER, HANNES C.A., LANG, SVEN A., STOELTZING, OLIVER, DIERMEIER-DAUCHER, SIMONE, BUCHDUNGER, ELISABETH, WOOD, JEANETTE, BOLD, GUIDO, BREIER, GEORG
Format: Online
Language:English
Published: D.A. Spandidos 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215578/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215578/

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