Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury

The aim of this study was to determine if complement pathway is activated in AKI; for this purpose, we measured, through ELISA sandwich, the terminal lytic fraction of the complement system, called membrane attack complex (C5b-C9), in AKI patients compared with patients with similar clinical conditi...

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Main Authors:	Rodríguez, Eva, Riera, Marta, Barrios, Clara, Pascual, Julio
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055497/

id	pubmed-4055497
recordtype	oai_dc
spelling	pubmed-40554972014-06-25 Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury Rodríguez, Eva Riera, Marta Barrios, Clara Pascual, Julio Research Article The aim of this study was to determine if complement pathway is activated in AKI; for this purpose, we measured, through ELISA sandwich, the terminal lytic fraction of the complement system, called membrane attack complex (C5b-C9), in AKI patients compared with patients with similar clinical conditions but normal renal function. Our data showed that complement system is activated in AKI. Plasmatic MAC concentrations were significantly higher in AKI patients than in those with normal renal function; this difference is maintained independently of the AKI etiology and is proportional to the severity of AKI, measured by ADQI classification. In addition, we found that plasmatic MAC concentrations were significantly higher in patients who did not recover renal function at time of hospitalization discharge, in patients who died during the acute process, and in patients who need renal replacement therapy during hospitalization, but in this last group, the differences did not reach statistical significance. In conclusion, plasmatic MAC concentration seems valuable as a marker of AKI severity. Hindawi Publishing Corporation 2014 2014-05-25 /pmc/articles/PMC4055497/ /pubmed/24967359 http://dx.doi.org/10.1155/2014/361065 Text en Copyright © 2014 Eva Rodríguez et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Rodríguez, Eva Riera, Marta Barrios, Clara Pascual, Julio
spellingShingle	Rodríguez, Eva Riera, Marta Barrios, Clara Pascual, Julio Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury
author_facet	Rodríguez, Eva Riera, Marta Barrios, Clara Pascual, Julio
author_sort	Rodríguez, Eva
title	Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury
title_short	Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury
title_full	Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury
title_fullStr	Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury
title_full_unstemmed	Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury
title_sort	value of plasmatic membrane attack complex as a marker of severity in acute kidney injury
description	The aim of this study was to determine if complement pathway is activated in AKI; for this purpose, we measured, through ELISA sandwich, the terminal lytic fraction of the complement system, called membrane attack complex (C5b-C9), in AKI patients compared with patients with similar clinical conditions but normal renal function. Our data showed that complement system is activated in AKI. Plasmatic MAC concentrations were significantly higher in AKI patients than in those with normal renal function; this difference is maintained independently of the AKI etiology and is proportional to the severity of AKI, measured by ADQI classification. In addition, we found that plasmatic MAC concentrations were significantly higher in patients who did not recover renal function at time of hospitalization discharge, in patients who died during the acute process, and in patients who need renal replacement therapy during hospitalization, but in this last group, the differences did not reach statistical significance. In conclusion, plasmatic MAC concentration seems valuable as a marker of AKI severity.
publisher	Hindawi Publishing Corporation
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055497/
_version_	1612100443379335168

Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury

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