Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion
Mutations in subunits of succinyl-CoA synthetase/ligase (SCS), a component of the citric acid cycle, are associated with mitochondrial encephalomyopathy, elevation of methylmalonic acid (MMA), and mitochondrial DNA (mtDNA) depletion. A FACS-based retroviral-mediated gene trap mutagenesis screen in m...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Company of Biologists Limited
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917248/ |