HIV-1 Vpr Accelerates Viral Replication during Acute Infection by Exploitation of Proliferating CD4+ T Cells In Vivo

HIV-1 Vpr Accelerates Viral Replication during Acute Infection by Exploitation of Proliferating CD4+ T Cells In Vivo

The precise role of viral protein R (Vpr), an HIV-1-encoded protein, during HIV-1 infection and its contribution to the development of AIDS remain unclear. Previous reports have shown that Vpr has the ability to cause G2 cell cycle arrest and apoptosis in HIV-1-infected cells in vitro. In addition,...

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Bibliographic Details
Main Authors: Sato, Kei, Misawa, Naoko, Iwami, Shingo, Satou, Yorifumi, Matsuoka, Masao, Ishizaka, Yukihito, Ito, Mamoru, Aihara, Kazuyuki, An, Dong Sung, Koyanagi, Yoshio
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855622/

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