Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain
p62 has been proposed to mark ubiquitinated protein bodies for autophagic degradation. We report that the Drosophila melanogaster p62 orthologue, Ref(2)P, is a regulator of protein aggregation in the adult brain. We demonstrate that Ref(2)P localizes to age-induced protein aggregates as well as to a...
| Main Authors: | , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2008
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290837/ |