The Tissue Plasminogen Activator (Tpa/Plasmin) Extracellular Proteolytic System Regulates Seizure-Induced Hippocampal Mossy Fiber Outgrowth through a Proteoglycan Substrate

The Tissue Plasminogen Activator (Tpa/Plasmin) Extracellular Proteolytic System Regulates Seizure-Induced Hippocampal Mossy Fiber Outgrowth through a Proteoglycan Substrate

Short seizure episodes are associated with remodeling of neuronal connections. One region where such reorganization occurs is the hippocampus, and in particular, the mossy fiber pathway. Using genetic and pharmacological approaches, we show here a critical role in vivo for tissue plasminogen activat...

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Bibliographic Details
Main Authors: Wu, Yan Ping, Siao, Chia-Jen, Lu, Weiquan, Sung, Tsung-Chang, Frohman, Michael A., Milev, Peter, Bugge, Thomas H., Degen, Jay L., Levine, Joel M., Margolis, Richard U., Tsirka, Stella E.
Format: Online
Language:English
Published: The Rockefeller University Press 2000
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174310/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174310/

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