SAP regulates T cell–mediated help for humoral immunity by a mechanism distinct from cytokine regulation
X-linked lymphoproliferative disease is caused by mutations affecting SH2D1A/SAP, an adaptor that recruits Fyn to signal lymphocyte activation molecule (SLAM)-related receptors. After infection, SLAM-associated protein (SAP)−/− mice show increased T cell activation and impaired humoral responses. Al...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2006
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118305/ |