Clinical significance of serum soluble B7-H3 in patients with osteosarcoma

Abstract Background Increasing data has indicated an association between increased soluble B7-H3 (sB7-H3) levels and unfavorable prognosis in patients with malignancies. However, the level of sB7-H3 and its clinical significance in osteosarcoma (OS) are not well known. In this present study, we inve...

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Main Authors:	Ling Wang, Fu-biao Kang, Guo-chuan Zhang, Juan Wang, Ming-fang Xie, Ying-ze Zhang
Format:	Article
Language:	English
Published:	BioMed Central 2018-08-01
Series:	Cancer Cell International
Subjects:	Osteosarcoma B7-H3 Tumor biomarker Bone tumor Prognosis
Online Access:	http://link.springer.com/article/10.1186/s12935-018-0614-z

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spelling	doaj-art-bca1c887ae604d1eaae1aca18effe60c2018-08-16T00:31:27ZengBioMed CentralCancer Cell International1475-28672018-08-011811810.1186/s12935-018-0614-zClinical significance of serum soluble B7-H3 in patients with osteosarcomaLing Wang0Fu-biao Kang1Guo-chuan Zhang2Juan Wang3Ming-fang Xie4Ying-ze Zhang5Department of Orthopedic Oncology, The Third Hospital of Hebei Medical UniversityDepartment of Liver Diseases, Bethune International Peace HospitalDepartment of Orthopedic Oncology, The Third Hospital of Hebei Medical UniversityDepartment of Orthopedic Surgery, The Third Hospital of Hebei Medical UniversityDepartment of Orthopedic Oncology, The Third Hospital of Hebei Medical UniversityDepartment of Orthopedic Research Center, The Third Hospital of Hebei Medical UniversityAbstract Background Increasing data has indicated an association between increased soluble B7-H3 (sB7-H3) levels and unfavorable prognosis in patients with malignancies. However, the level of sB7-H3 and its clinical significance in osteosarcoma (OS) are not well known. In this present study, we investigated whether sB7-H3 levels in serum could be as a tool for differential diagnosis of OS patients. Methods Peripheral blood samples from healthy controls, benign bone tumors, and OS patients were collected. Levels of sB7-H3 in serum samples were measured by enzyme-linked immunosorbent assays. The correlation between OS-derived sB7-H3 and clinical features was analyzed, and prognostic significance of the sB7-H3 concentrations and tumor expressions of the biomarkers was then evaluated. Results sB7-H3 concentrations were significantly increased in patients with OS than in osteochondroma patients, bone fibrous dysplasia patients and healthy people (p < 0.05, respectively). Using 60.94 ng/mL as a cutoff value, the sensitivity and specificity of sB7-H3 was to differentiate between OS patients and other bone benign tumor patients were 75.7% and 83.8%, respectively. In addition, upregulated serum sB7-H3 in patients with OS associated with tumor differentiation, tumor stage, and metastasis status (p < 0.05, respectively). The area under the curve value for sB7-H3 (0.868) was markedly higher than those for ALP (0.713) and CA125 (0.789) for differentiating between OS patients and other begin bone tumor patients. Conclusions We demonstrated that enhanced sB7-H3 levels correlated with the clinical characteristics of OS patients, and B7-H3 might be a potential biomarker and associated with the pathogenesis of OS.http://link.springer.com/article/10.1186/s12935-018-0614-zOsteosarcomaB7-H3Tumor biomarkerBone tumorPrognosis
institution	Open Data Bank
collection	Open Access Journals
building	Directory of Open Access Journals
language	English
format	Article
author	Ling Wang Fu-biao Kang Guo-chuan Zhang Juan Wang Ming-fang Xie Ying-ze Zhang
spellingShingle	Ling Wang Fu-biao Kang Guo-chuan Zhang Juan Wang Ming-fang Xie Ying-ze Zhang Clinical significance of serum soluble B7-H3 in patients with osteosarcoma Cancer Cell International Osteosarcoma B7-H3 Tumor biomarker Bone tumor Prognosis
author_facet	Ling Wang Fu-biao Kang Guo-chuan Zhang Juan Wang Ming-fang Xie Ying-ze Zhang
author_sort	Ling Wang
title	Clinical significance of serum soluble B7-H3 in patients with osteosarcoma
title_short	Clinical significance of serum soluble B7-H3 in patients with osteosarcoma
title_full	Clinical significance of serum soluble B7-H3 in patients with osteosarcoma
title_fullStr	Clinical significance of serum soluble B7-H3 in patients with osteosarcoma
title_full_unstemmed	Clinical significance of serum soluble B7-H3 in patients with osteosarcoma
title_sort	clinical significance of serum soluble b7-h3 in patients with osteosarcoma
publisher	BioMed Central
series	Cancer Cell International
issn	1475-2867
publishDate	2018-08-01
description	Abstract Background Increasing data has indicated an association between increased soluble B7-H3 (sB7-H3) levels and unfavorable prognosis in patients with malignancies. However, the level of sB7-H3 and its clinical significance in osteosarcoma (OS) are not well known. In this present study, we investigated whether sB7-H3 levels in serum could be as a tool for differential diagnosis of OS patients. Methods Peripheral blood samples from healthy controls, benign bone tumors, and OS patients were collected. Levels of sB7-H3 in serum samples were measured by enzyme-linked immunosorbent assays. The correlation between OS-derived sB7-H3 and clinical features was analyzed, and prognostic significance of the sB7-H3 concentrations and tumor expressions of the biomarkers was then evaluated. Results sB7-H3 concentrations were significantly increased in patients with OS than in osteochondroma patients, bone fibrous dysplasia patients and healthy people (p < 0.05, respectively). Using 60.94 ng/mL as a cutoff value, the sensitivity and specificity of sB7-H3 was to differentiate between OS patients and other bone benign tumor patients were 75.7% and 83.8%, respectively. In addition, upregulated serum sB7-H3 in patients with OS associated with tumor differentiation, tumor stage, and metastasis status (p < 0.05, respectively). The area under the curve value for sB7-H3 (0.868) was markedly higher than those for ALP (0.713) and CA125 (0.789) for differentiating between OS patients and other begin bone tumor patients. Conclusions We demonstrated that enhanced sB7-H3 levels correlated with the clinical characteristics of OS patients, and B7-H3 might be a potential biomarker and associated with the pathogenesis of OS.
topic	Osteosarcoma B7-H3 Tumor biomarker Bone tumor Prognosis
url	http://link.springer.com/article/10.1186/s12935-018-0614-z
_version_	1612697356898140160

Clinical significance of serum soluble B7-H3 in patients with osteosarcoma

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