Pancreatic cancer genomics: insights and opportunities for clinical translation

by Makohon-Moore, Alvin, Brosnan, Jacqueline A, Iacobuzio-Donahue, Christine A
Published 2013

Cronkhite-Canada Syndrome: Gastric Involvement Diagnosed by MDCT

by Samet, Jonathan D., Horton, Karen M., Fishman, Elliot K., Iacobuzio-Donahue, Christine A.
Published 2009

HMGA1 Induces Intestinal Polyposis in Transgenic Mice and Drives Tumor Progression and Stem Cell Properties in Colon Cancer Cells

by Belton, Amy, Gabrovsky, Alexander, Bae, Young Kyung, Reeves, Ray, Iacobuzio-Donahue, Christine, Huso, David L., Resar, Linda M. S.
Published 2012

Loss of E-Cadherin Expression and Outcome among Patients with Resectable Pancreatic Adenocarcinomas

by Hong, Seung-Mo, Li, Ang, Olino, Kelly, Wolfgang, Christopher L., Herman, Joseph M., Schulick, Richard D., Iacobuzio-Donahue, Christine, Hruban, Ralph H., Goggins, Michael
Published 2011

Heteroplasmic mitochondrial DNA mutations in normal and tumor cells

by He, Yiping, Wu, Jian, Dressman, Devin C., Iacobuzio-Donahue, Christine, Markowitz, Sanford D., Velculescu, Victor E., Diaz, Luis A., Kinzler, Kenneth W., Vogelstein, Bert, Papadopoulos, Nickolas
Published 2010

Distant Metastasis Occurs Late during the Genetic Evolution of Pancreatic Cancer

by Yachida, Shinichi, Jones, Siân, Bozic, Ivana, Antal, Tibor, Leary, Rebecca, Fu, Baojin, Kamiyama, Mihoko, Hruban, Ralph H., Eshleman, James R., Nowak, Martin A., Velculescu, Victor E., Kinzler, Kenneth W., Vogelstein, Bert, Iacobuzio-Donahue, Christine A.
Published 2010

GATA6 Activates Wnt Signaling in Pancreatic Cancer by Negatively Regulating the Wnt Antagonist Dickkopf-1

by Zhong, Yi, Wang, Zheng, Fu, Baojin, Pan, Fan, Yachida, Shinichi, Dhara, Mousumi, Albesiano, Emilia, Li, Li, Naito, Yoshiki, Vilardell, Felip, Cummings, Christopher, Martinelli, Paola, Li, Ang, Yonescu, Raluca, Ma, Qingyong, Griffin, Constance A., Real, Francisco X., Iacobuzio-Donahue, Christine A.
Published 2011

Disruption of p16 and Activation of Kras in Pancreas Increase Ductal Adenocarcinoma Formation and Metastasis in vivo

by Qiu, Wanglong, Sahin, Fikret, Iacobuzio-Donahue, Christine A., Garcia-Carracedo, Dario, Wang, Wendy M., Kuo, Chia-Yu, Chen, Doris, Arking, Dan E., Lowy, Andrew M., Hruban, Ralph H., Remotti, Helen E., Su, Gloria H.
Published 2011

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers

by Haffner, Michael C., Chaux, Alcides, Meeker, Alan K., Esopi, David M., Gerber, Jonathan, Pellakuru, Laxmi G., Toubaji, Antoun, Argani, Pedram, Iacobuzio-Donahue, Christine, Nelson, William G., Netto, George J., De Marzo, Angelo M., Yegnasubramanian, Srinivasan
Published 2011

HMGA1 Correlates with Advanced Tumor Grade and Decreased Survival in Pancreatic Ductal Adenocarcinoma

by Hristov, Alexandra C., Cope, Leslie, Di Cello, Francescopaolo, Reyes, Marcelo Delos, Singh, Mansher, Hillion, Joelle, Belton, Amy, Joseph, Biju, Schuldenfrei, Andrew, Iacobuzio-Donahue, Christine, Maitra, Anirban, Resar, Linda M. S.
Published 2009

RhoC Interacts with Integrin α5β1 and Enhances Its Trafficking in Migrating Pancreatic Carcinoma Cells

by Li, Ningfeng Fiona, Gemenetzidis, Emilios, Marshall, Francis J., Davies, Derek, Yu, Yongwei, Frese, Kristopher, Froeling, Fieke E. M., Woolf, Adam K., Feakins, Roger M., Naito, Yoshiki, Iacobuzio-Donahue, Christine, Tuveson, David A., Hart, Ian R., Kocher, Hemant M.
Published 2013

Metastatic progression is associated with dynamic changes in the local microenvironment

by Aiello, Nicole M., Bajor, David L., Norgard, Robert J., Sahmoud, Amine, Bhagwat, Neha, Pham, Minh N., Cornish, Toby C., Iacobuzio-Donahue, Christine A., Vonderheide, Robert H., Stanger, Ben Z.
Published 2016

Somatic Mutations in the Chromatin Remodeling Gene ARID1A Occur in Several Tumor Types

by Jones, Siân, Li, Meng, Parsons, D Williams, Zhang, Xiaosong, Wesseling, Jelle, Kristel, Petra, Schmidt, Marjanka K, Markowitz, Sanford, Yan, Hai, Bigner, Darell, Hruban, Ralph H, Eshleman, James R, Iacobuzio-Donahue, Christine A, Goggins, Michael, Maitra, Anirban, Malek, Sami N, Powell, Steve, Vogelstein, Bert, Kinzler, Kenneth W, Velculescu, Victor E, Papadopoulos, Nickolas
Published 2012

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

by DeNicola, Gina M., Karreth, Florian A., Humpton, Timothy J., Gopinathan, Aarthi, Wei, Cong, Frese, Kristopher, Mangal, Dipti, Yu, Kenneth H., Yeo, Charles J., Calhoun, Eric S., Scrimieri, Francesca, Winter, Jordan M., Hruban, Ralph H., Iacobuzio-Donahue, Christine, Kern, Scott E., Blair, Ian A., Tuveson, David A.
Published 2011

Deep Clonal Profiling of Formalin Fixed Paraffin Embedded Clinical Samples

by Holley, Tara, Lenkiewicz, Elizabeth, Evers, Lisa, Tembe, Waibhav, Ruiz, Christian, Gsponer, Joel R., Rentsch, Cyrill A., Bubendorf, Lukas, Stapleton, Mark, Amorese, Doug, Legendre, Christophe, Cunliffe, Heather E., McCullough, Ann E., Pockaj, Barbara, Craig, David, Carpten, John, Von Hoff, Daniel, Iacobuzio-Donahue, Christine, Barrett, Michael T.
Published 2012

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular-fibrosis and tumor progression

by Laklai, Hanane, Miroshnikova, Yekaterina A., Pickup, Michael W., Collisson, Eric A., Kim, Grace E., Barrett, Alex S., Hill, Ryan C., Lakins, Johnathon N., Schlaepfer, David D., Mouw, Janna K., LeBleu, Valerie S., Roy, Nilotpal, Novitskiy, Sergey V., Johansen, Julia S., Poli, Valeria, Kalluri, Raghu, Iacobuzio-Donahue, Christine A., Wood, Laura D., Hebrok, Matthias, Hansen, Kirk, Moses, Harold L., Weaver, Valerie M.
Published 2016

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

by Moffitt, Richard A., Marayati, Raoud, Flate, Elizabeth L., Volmar, Keith E., Loeza, S. Gabriela Herrera, Hoadley, Katherine A., Rashid, Naim U., Williams, Lindsay A., Eaton, Samuel C., Chung, Alexander H., Smyla, Jadwiga K., Anderson, Judy M., Kim, Hong Jin, Bentrem, David J., Talamonti, Mark S., Iacobuzio-Donahue, Christine A., Hollingsworth, Michael A., Yeh, Jen Jen
Published 2015

Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma

by Rodić, Nemanja, Steranka, Jared P., Makohon-Moore, Alvin, Moyer, Allison, Shen, Peilin, Sharma, Reema, Kohutek, Zachary A., Huang, Cheng Ran, Ahn, Daniel, Mita, Paolo, Taylor, Martin S., Barker, Norman J., Hruban, Ralph H., Iacobuzio-Donahue, Christine A., Boeke, Jef D., Burns, Kathleen H.
Published 2015

Phase 2 Multi-institutional Trial Evaluating Gemcitabine and Stereotactic Body Radiotherapy for Patients With Locally Advanced Unresectable Pancreatic Adenocarcinoma

by Herman, Joseph M, Chang, Daniel T, Goodman, Karyn A, Dholakia, Avani S, Raman, Siva P, Hacker-Prietz, Amy, Iacobuzio-Donahue, Christine A, Griffith, Mary E, Pawlik, Timothy M, Pai, Jonathan S, O'Reilly, Eileen, Fisher, George A, Wild, Aaron T, Rosati, Lauren M, Zheng, Lei, Wolfgang, Christopher L, Laheru, Daniel A, Columbo, Laurie A, Sugar, Elizabeth A, Koong, Albert C
Published 2015

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

by Campbell, Peter J, Yachida, Shinichi, Mudie, Laura J, Stephens, Philip J, Pleasance, Erin D, Stebbings, Lucy A, Morsberger, Laura A, Latimer, Calli, McLaren, Stuart, Lin, Meng-Lay, McBride, David J, Varela, Ignacio, Nik-Zainal, Serena A, Leroy, Catherine, Jia, Mingming, Menzies, Andrew, Butler, Adam P, Teague, Jon W, Griffin, Constance A, Burton, John, Swerdlow, Harold, Quail, Michael A, Stratton, Michael R, Iacobuzio-Donahue, Christine, Futreal, P Andrew
Published 2010