Experimental and Therapeutic Opportunities for Stem Cells in Multiple Sclerosis

by Patani, Rickie, Chandran, Siddharthan
Published 2012

Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration

by Gupta, Kunal, Chandran, Siddharthan, Hardingham, Giles E
Published 2013

NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons

by Gupta, Kunal, Hardingham, Giles E., Chandran, Siddharthan
Published 2013

Unpicking neurodegeneration in a dish with human pluripotent stem cells: One cell type at a time

by Bilican, Bilada, Serio, Andrea, Shaw, Christopher E, Maniatis, Tom, Chandran, Siddharthan
Published 2013

Hypothermic Preconditioning of Human Cortical Neurons Requires Proteostatic Priming

by Rzechorzek, Nina Marie, Connick, Peter, Patani, Rickie, Selvaraj, Bhuvaneish Thangaraj, Chandran, Siddharthan
Published 2015

Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells

by Livesey, Matthew R., Magnani, Dario, Hardingham, Giles E., Chandran, Siddharthan, Wyllie, David J. A.
Published 2015

High Yields of Oligodendrocyte Lineage Cells from Human Embryonic Stem Cells at Physiological Oxygen Tensions for Evaluation of Translational Biology

by Stacpoole, Sybil R.L., Spitzer, Sonia, Bilican, Bilada, Compston, Alastair, Karadottir, Ragnhildur, Chandran, Siddharthan, Franklin, Robin J.M.
Published 2013

Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis

by Hampton, David W, Serio, Andrea, Pryce, Gareth, Al-Izki, Sarah, Franklin, Robin JM, Giovannoni, Gavin, Baker, David, Chandran, Siddharthan
Published 2013

Mesenchymal Stem Cells Lack Efficacy in the Treatment of Experimental Autoimmune Neuritis despite In Vitro Inhibition of T-Cell Proliferation

by Sajic, Marija, Hunt, David P. J., Lee, Woojin, Compston, D. Alastair S., Schweimer, Judith V., Gregson, Norman A., Chandran, Siddharthan, Smith, Kenneth J.
Published 2012

Physiological Normoxia and Absence of EGF Is Required for the Long-Term Propagation of Anterior Neural Precursors from Human Pluripotent Cells

by Bilican, Bilada, Livesey, Matthew R., Haghi, Ghazal, Qiu, Jing, Burr, Karen, Siller, Rick, Hardingham, Giles E., Wyllie, David J. A., Chandran, Siddharthan
Published 2014

Improved PCR based methods for detecting C9orf72 hexanucleotide repeat expansions

by Cleary, Elaine M., Pal, Suvankar, Azam, Tara, Moore, David J., Swingler, Robert, Gorrie, George, Stephenson, Laura, Colville, Shuna, Chandran, Siddharthan, Porteous, Mary, Warner, Jon P.
Published 2016

Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition

by Rzechorzek, Nina M., Connick, Peter, Livesey, Matthew R., Borooah, Shyamanga, Patani, Rickie, Burr, Karen, Story, David, Wyllie, David J.A., Hardingham, Giles E., Chandran, Siddharthan
Published 2015

Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability

by Devlin, Anna-Claire, Burr, Karen, Borooah, Shyamanga, Foster, Joshua D., Cleary, Elaine M., Geti, Imbisaat, Vallier, Ludovic, Shaw, Christopher E., Chandran, Siddharthan, Miles, Gareth B.
Published 2015

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models

by Barmada, Sami J., Serio, Andrea, Arjun, Arpana, Bilican, Bilada, Daub, Aaron, Ando, D. Michael, Tsvetkov, Andrey, Pleiss, Michael, Li, Xingli, Peisach, Daniel, Shaw, Christopher, Chandran, Siddharthan, Finkbeiner, Steven
Published 2014

Drug Repurposing: A Systematic Approach to Evaluate Candidate Oral Neuroprotective Interventions for Secondary Progressive Multiple Sclerosis

by Vesterinen, Hanna M., Connick, Peter, Irvine, Cadi M. J., Sena, Emily S., Egan, Kieren J., Carmichael, Gary G., Tariq, Afiyah, Pavitt, Sue, Chataway, Jeremy, Macleod, Malcolm R., Chandran, Siddharthan
Published 2015

Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study

by Connick, Peter, Kolappan, Madhan, Crawley, Charles, Webber, Daniel J, Patani, Rickie, Michell, Andrew W, Du, Ming-Qing, Luan, Shi-Lu, Altmann, Daniel R, Thompson, Alan J, Compston, Alastair, Scott, Michael A, Miller, David H, Chandran, Siddharthan
Published 2012

Characterising the RNA targets and position-dependent splicing regulation by TDP-43; implications for neurodegenerative diseases

by Tollervey, James R., Curk, Tomaž, Rogelj, Boris, Briese, Michael, Cereda, Matteo, Kayikci, Melis, Hortobágyi, Tibor, Nishimura, Agnes L., Župunski, Vera, Patani, Rickie, Chandran, Siddharthan, Rot, Gregor, Zupan, Blaž, Shaw, Christopher E., Ule, Jernej
Published 2011

Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development

by Ruzov, Alexey, Tsenkina, Yanina, Serio, Andrea, Dudnakova, Tatiana, Fletcher, Judy, Bai, Yu, Chebotareva, Tatiana, Pells, Steve, Hannoun, Zara, Sullivan, Gareth, Chandran, Siddharthan, Hay, David C, Bradley, Mark, Wilmut, Ian, De Sousa, Paul
Published 2011

Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis

by Patani, Rickie, Lewis, Patrick A, Trabzuni, Daniah, Puddifoot, Clare A, Wyllie, David J A, Walker, Robert, Smith, Colin, Hardingham, Giles E, Weale, Michael, Hardy, John, Chandran, Siddharthan, Ryten, Mina
Published 2012

Allele-Specific Knockdown of ALS-Associated Mutant TDP-43 in Neural Stem Cells Derived from Induced Pluripotent Stem Cells

by Nishimura, Agnes L., Shum, Carole, Scotter, Emma L., Abdelgany, Amr, Sardone, Valentina, Wright, Jamie, Lee, Youn-Bok, Chen, Han-Jou, Bilican, Bilada, Carrasco, Monica, Maniatis, Tom, Chandran, Siddharthan, Rogelj, Boris, Gallo, Jean-Marc, Shaw, Christopher E.
Published 2014